Rich experience (>15 years) on the construction of versatile macrocyclic compounds, more than 8 representative cyclization methods have been developed Macrocyclic Cpds such as lactam, lactone, sulfonamides, ethers, bi-cyclic & tri-cyclic, etc. can be efficiently synthesized, more than 1500 macrocyclic compounds have been prepared and >30 g of desired products with 20-31 steps have been obtained
Mitsunobu Cyclization
RCM Cyclization
Sulfonamide Formation
Lactam Cyclization
Substitution Cyclization
Click Reaction
Reductive Amination
C-H Activation