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Small Molecule
Small Molecule
WuXi TIDES(Oligonucleotide and Peptide CRDMO Service)
C"R"DMO
C"R"DMO
CR"DM'O
PROTAC <sup>®</sup> Platform
Carbohydrate Chemistry
Nucleoside/tide
Macrocyclic Chemistry
Boron Chemistry
Steroids Chemistry
Nanomedicine
Computer-aided Drug Design
Library
Compound Management
Reaction Condition Screening
Fluorescent Bio-probe and Labeling
Quantum Mechanics
Late Stage Functionalization
Catalysis Screening
Custom Synthesis
Discovery Process Chemistry
Bio-transformation
Impurity Proofing
Isotopic Labeling Chemistry
Crystallization Platform
Analysis & Purification
Fluorine Chemistry
PROTAC <sup>®</sup> Platform
Flow Chemistry Service
Electrochemistry
Photoredox Chemistry
We have 900+ chemists with considerable experiences in the linkers, E3 ligase ligand and target protein ligand synthesis since 2016
>60 clients/collaborations
>50 methods of Prep-HPLC and chiral-SFC for purification
Efficient in-vitro/in-vivo testing by WuXi DMPK
Experienced in versatile linkers synthesis, 100+ are readily available
Novel linker synthesis by high productivity, quality, speed, and reliability PROTAC ® Platform
Experienced in CRBN/VHL/IAP/MDM2 and novel E3 ligase ligands synthesis, >30 CRBN/VHL ligands are readily available
30 series of target protein ligands coupled with various linkers
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
A modular platform:More efficient PROTAC®synthesis
Customized PROTAC®: From mg scale to 200+ kg
Linkers: Most frequently used linkers, e.g. PEG, alkyl, ”clickable”, and rigid linkers
In-stock compounds:More than 350 in-stock linkers or E3 ligase ligands based on literatures
E3 ligase ligands: Common ligands are readily available, e.g. VHL, CRBN, cIAP, etc
From mg to hundreds of kg
> 20,000 compounds synthesized
> 90% on-time delivery
> 100 libraries finished
1~5 step parallel synthesis
2~4 weeks of turn-around time