[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”4.16″ global_colors_info=”{}”][et_pb_fullwidth_header title=”Drug Metabolism and Pharmacokinetic Services” _builder_version=”4.16″ title_font=”||||||||” title_font_size=”60px” background_color=”rgba(255,255,255,0)” background_image=”https:\/\/labtesting.\/wp-content\/uploads\/2020\/04\/hdr_dmpk.jpg” custom_margin=”|||” custom_padding=”8%||8%|” custom_padding_tablet=”” custom_padding_phone=”” custom_padding_last_edited=”on|phone” title_font_size_tablet=”30″ title_font_size_phone=”” title_font_size_last_edited=”on|phone” title_text_shadow_style=”preset2″ title_text_shadow_horizontal_length=”0.03em” title_text_shadow_vertical_length=”0.03em” title_text_shadow_blur_strength=”0.1em” title_text_shadow_color=”rgba(0,0,0,0.6)” saved_tabs=”all” global_colors_info=”{}” button_one_text_size__hover_enabled=”off” button_one_text_size__hover=”null” button_two_text_size__hover_enabled=”off” button_two_text_size__hover=”null” button_one_text_color__hover_enabled=”off” button_one_text_color__hover=”null” button_two_text_color__hover_enabled=”off” button_two_text_color__hover=”null” button_one_border_width__hover_enabled=”off” button_one_border_width__hover=”null” button_two_border_width__hover_enabled=”off” button_two_border_width__hover=”null” button_one_border_color__hover_enabled=”off” button_one_border_color__hover=”null” button_two_border_color__hover_enabled=”off” button_two_border_color__hover=”null” button_one_border_radius__hover_enabled=”off” button_one_border_radius__hover=”null” button_two_border_radius__hover_enabled=”off” button_two_border_radius__hover=”null” button_one_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover=”null” button_two_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover=”null” button_one_bg_color__hover_enabled=”off” button_one_bg_color__hover=”null” button_two_bg_color__hover_enabled=”off” button_two_bg_color__hover=”null”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.23″ _module_preset=”default” global_colors_info=”{}”][et_pb_row column_structure=”1_3,2_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.23″ _module_preset=”default” global_colors_info=”{}”][et_pb_cta title=”Speak With a Scientist” button_url=”https:\/\/labtesting.\/talk-to-an-expert” button_text=”Speak with a Scientist” _builder_version=”4.23.4″ _dynamic_attributes=”button_url” header_font_size=”28px” header_line_height=”1.2em” body_font_size=”13px” body_line_height=”1.3em” custom_button=”on” button_text_color=”#008064″ button_bg_color=”#ffffff” button_use_icon=”off” min_height=”100.3px” custom_margin=”0px|20px|||false|false” custom_padding=”24px|20px|24px|20px|true|true” sticky_position=”top” sticky_limit_bottom=”row” scroll_scaling=”0|51|51|100|70|100|100″ global_module=”6523″ saved_tabs=”all” global_colors_info=”{}” button_bg_color__hover_enabled=”on|desktop” button_bg_color__hover=”rgba(255,255,255,0.8)” button_bg_enable_color__hover=”on”]<\/p>\n
about your upcoming project to see how we can help you<\/span><\/p>\n [\/et_pb_cta][et_pb_cta button_url=”https:\/\/go.labtesting.\/get-a-quote” button_text=”Get a Quote” admin_label=”Call To Action” _builder_version=”4.18.0″ _dynamic_attributes=”button_url” header_font_size=”28px” header_line_height=”1.2em” body_font_size=”13px” body_line_height=”1.3em” background_color=”#0071BC” custom_button=”on” button_text_color=”#0071BC” button_bg_color=”#ffffff” button_use_icon=”off” min_height=”100.3px” custom_margin=”0px|20px|||false|false” custom_padding=”32px|20px|24px|20px|false|true” global_module=”6799″ saved_tabs=”all” global_colors_info=”{}” button_bg_color__hover_enabled=”on|desktop” button_bg_color__hover=”rgba(255,255,255,0.8)” button_bg_enable_color__hover=”on”][\/et_pb_cta][et_pb_sidebar area=”et_pb_widget_area_2″ disabled_on=”off|off|off” admin_label=”dmpk sidebar” _builder_version=”4.18.0″ header_font=”||||||||” body_font=”||||||||” z_index=”0″ text_orientation=”right” max_width=”100%” text_orientation_tablet=”left” text_orientation_phone=”” text_orientation_last_edited=”on|desktop” global_module=”3318″ saved_tabs=”all” global_colors_info=”{}”][\/et_pb_sidebar][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.23″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n Shifting the focus of DMPK\/ADME studies to an earlier stage in the discovery process can play a pivotal role in reducing the likelihood of compound failure. This strategic realignment not only aids in establishing compound potency against a target while ensuring safety but also fine-tunes PK parameters to enhance effectiveness. Additionally, it mitigates the potential for drug-drug interactions (DDIs). Subsequently, during later stages, ADME studies further validate toxicological assessments, provide crucial backing for safety evaluations before First-in-Human (FIH) trials, and offer insights into the probability of encountering DDIs.<\/span><\/p>\n [\/et_pb_text][et_pb_video src=/Other/labtesting/wp-json/wp/v2/pages/&/index.html image_src=/Other/labtesting/wp-json/wp/v2/pages/&/index.html _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_video][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.18.0″ _module_preset=”default” background_color=”#f2f2f2″ global_colors_info=”{}”][et_pb_row _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Consulting Services” _builder_version=”4.18.0″ text_font=”||||||||” header_line_height=”1.3em” text_text_align=”left” global_colors_info=”{}”]<\/p>\n Effective DMPK\/ADME studies require a full understanding of your specific needs and challenges. This allows our team to build a program tailored to the needs of your compound and timeline. Whether providing stand-alone or integrated services, our DMPK\/ADME team collaborates closely with our chemistry, biology and pharmacology groups to support your compound\u2019s design and selection during the discovery stage.<\/span><\/p>\n [\/et_pb_text][et_pb_image src=/Other/labtesting/wp-json/wp/v2/pages/&/index.html title_text=”DMPK-graphic1″ _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ inner_shadow=”on” admin_label=”At a Glance” _builder_version=”4.16″ use_background_color_gradient=”on” background_color_gradient_stops=”#00b68e 0%|#008064 100%” background_color_gradient_start=”#00b68e” background_color_gradient_end=”#008064″ background_image=”https:\/\/labtesting.\/wp-content\/uploads\/2020\/03\/lines.svg” background_blend=”soft-light” width=”100%” module_alignment=”center” custom_padding=”54px|0px|54px|0px|false|false” locked=”off” collapsed=”on” 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module_class=”plus” _builder_version=”4.18.0″ title_level=”h6″ title_font=”Open Sans||||||||” title_text_color=”#ffffff” number_font=”|700|||||||” number_text_color=”#ffffff” number_font_size=”70px” width=”100%” custom_css_percent=”.plus .percent-value:after { content:’+’;}” global_colors_info=”{}”][\/et_pb_number_counter][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_number_counter title=”Global Clients” number=”1,500″ percent_sign=”off” module_class=”plus” _builder_version=”4.18.0″ title_level=”h6″ title_font=”Open Sans||||||||” title_text_color=”#ffffff” number_font=”|700|||||||” number_text_color=”#ffffff” number_font_size=”70px” custom_css_percent=”.plus .percent-value:after { content:’+’;}” global_colors_info=”{}”][\/et_pb_number_counter][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_number_counter title=”Successful IND Filings” number=”1,200″ percent_sign=”off” module_class=”plus” _builder_version=”4.18.0″ title_level=”h6″ title_font=”Open Sans||||||||” title_text_color=”#ffffff” number_font=”|700|||||||” number_text_color=”#ffffff” number_font_size=”70px” custom_css_percent=”.plus .percent-value:after { content:’+’;}” global_colors_info=”{}”][\/et_pb_number_counter][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.18.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_padding=”||||false|false” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_number_counter title=”Assay Types” number=”200″ percent_sign=”off” module_class=”plus” _builder_version=”4.18.0″ title_level=”h6″ title_font=”Open Sans||||||||” title_text_color=”#ffffff” number_font=”|700|||||||” number_text_color=”#ffffff” number_font_size=”70px” custom_css_percent=”.plus .percent-value:after { content:’+’;}” global_colors_info=”{}”][\/et_pb_number_counter][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_number_counter title=”In Vitro Studies\/Year” number=”300k” percent_sign=”off” module_class=”plus” _builder_version=”4.18.0″ title_level=”h6″ title_font=”Open Sans||||||||” title_text_color=”#ffffff” number_font=”|700|||||||” number_text_color=”#ffffff” number_font_size=”70px” width=”100%” custom_css_percent=”.plus .percent-value:after { content:’+’;}” global_colors_info=”{}”][\/et_pb_number_counter][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_number_counter title=”In Vivo Studies\/Year” number=”20k” percent_sign=”off” module_class=”plus” _builder_version=”4.18.0″ title_level=”h6″ title_font=”Open Sans||||||||” title_text_color=”#ffffff” number_font=”|700|||||||” number_text_color=”#ffffff” custom_css_percent=”.plus .percent-value:after { content:’+’;}” global_colors_info=”{}”][\/et_pb_number_counter][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_number_counter title=”Samples Analyzed\/Week” number=”180k” percent_sign=”off” module_class=”plus” _builder_version=”4.18.0″ title_level=”h6″ title_font=”Open Sans||||||||” title_text_color=”#ffffff” number_font=”|700|||||||” number_text_color=”#ffffff” number_font_size=”70px” custom_css_percent=”.plus .percent-value:after { content:’+’;}” global_colors_info=”{}”][\/et_pb_number_counter][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.18.0″ _module_preset=”default” background_color=”#f2f2f2″ global_colors_info=”{}”][et_pb_row _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Consulting Services” _builder_version=”4.25.0″ text_font=”||||||||” header_line_height=”1.3em” hover_enabled=”0″ text_text_align=”left” global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n Our DMPK services range from expert in vitro<\/em> ADME<\/a> and in vivo<\/em> PK to full-scale digital lab operation and management. We combine a full complement of services and expertise and open, transparent communication between teams and specializations, helping your project advance seamlessly through the life cycle.<\/span><\/p>\n [\/et_pb_text][et_pb_image src=/Other/labtesting/wp-json/wp/v2/pages/&/index.html title_text=”Asset 1@4x” _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ admin_label=”operations & compliance” _builder_version=”4.16″ min_height=”450.4px” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Regulatory Consulting Services” _builder_version=”4.18.0″ text_font=”||||||||” ul_font=”||||||||” width=”95.2%” text_text_align=”left” global_colors_info=”{}”]<\/p>\n In vitro<\/em> ADME studies<\/a> analyze how potential drugs are absorbed, distributed, metabolized, and excreted (ADME) within a controlled environment to predict efficacy, safety, and potential interactions, and reduce development costs.<\/span><\/p>\n <\/span><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=/Other/labtesting/wp-json/wp/v2/pages/&/index.html title_text=”wuxi-dmpk-pic44″ _builder_version=”4.18.0″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ admin_label=”operations & compliance” _builder_version=”4.16″ min_height=”414.4px” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=/Other/labtesting/wp-json/wp/v2/pages/&/index.html title_text=”wuxi-dmpk-pic99″ _builder_version=”4.18.0″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Regulatory Consulting Services” _builder_version=”4.18.0″ text_font=”||||||||” ul_font=”||||||||” text_text_align=”left” global_colors_info=”{}”]<\/p>\n In vivo<\/em> PK studies evaluate a drug’s pharmacokinetics (PK) to provide vital data on how the body processes a drug. This helps assess its efficacy, safety, and optimal dosing regimens during the drug development process.<\/span><\/p>\n <\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”3_5,2_5″ admin_label=”operations & compliance” _builder_version=”4.16″ min_height=”420.2px” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Regulatory Consulting Services” _builder_version=”4.18.0″ text_font=”||||||||” ul_font=”||||||||” text_text_align=”left” global_colors_info=”{}”]<\/p>\n Metabolite identification<\/a> examines the breakdown products of a drug\u2014metabolites\u2014within a biological system, helping understand their potential effects on a drug’s overall efficacy and safety profile.<\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=/Other/labtesting/wp-json/wp/v2/pages/&/index.html title_text=”wuxi-dmpk-pic11″ _builder_version=”4.18.0″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ admin_label=”operations & compliance” _builder_version=”4.16″ min_height=”396.4px” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=/Other/labtesting/wp-json/wp/v2/pages/&/index.html title_text=”pic5″ _builder_version=”4.18.0″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Regulatory Consulting Services” _builder_version=”4.18.0″ text_font=”||||||||” ul_font=”||||||||” text_text_align=”left” global_colors_info=”{}”]<\/p>\n Radiolabeled ADME studies<\/a> provide insights into a drug’s journey in the body, helping evaluate its behavior, potential accumulation, and elimination routes, which inform later-stage decision-making.<\/span><\/p>\n <\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”3_5,2_5″ admin_label=”operations & compliance” _builder_version=”4.16″ min_height=”395.2px” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Regulatory Consulting Services” _builder_version=”4.18.0″ text_font=”||||||||” ul_font=”||||||||” text_text_align=”left” global_colors_info=”{}”]<\/p>\n Non-GLP bioanalysis<\/a> involves evaluating drugs, metabolites, or biomarkers in biological matrices in a laboratory setting that does not adhere to the regulatory guidelines of Good Laboratory Practice (GLP)\u2014providing valuable early data for drug discovery and development.<\/span><\/p>\n <\/span><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=/Other/labtesting/wp-json/wp/v2/pages/&/index.html title_text=”pic6″ _builder_version=”4.18.0″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ admin_label=”operations & compliance” _builder_version=”4.16″ min_height=”336.9px” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=/Other/labtesting/wp-json/wp/v2/pages/&/index.html title_text=”pic7″ _builder_version=”4.18.0″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Regulatory Consulting Services” _builder_version=”4.18.0″ text_font=”||||||||” ul_font=”||||||||” text_text_align=”left” global_colors_info=”{}”]<\/p>\n Our digital lab operation services help streamline the management, storage, and logistics needs of your project to optimize workflows, minimize error, and ensure efficient and safe data delivery.<\/span><\/p>\n <\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.18.0″ _module_preset=”default” background_color=”#f2f2f2″ global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n Our expert DMPK\/ADME team can support a wide range of molecules and compounds, including new modalities. We offer a variety of study packages, from Investigational New Drug (IND)-Enabling to Definitive Drug-Drug Interaction (DDI) to Biotransformation and In Vivo<\/em> Absorption, distribution, Metabolism and Excretion (ADME).<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.18.0″ _module_preset=”default” width=”98.5%” global_colors_info=”{}”]<\/p>\nGlobal DMPK\/ADME Studies<\/h2>\n
Integrated Drug Metabolism & Pharmacokinetics <\/h2>\n
Comprehensive DMPK\/ADME Services<\/h2>\n
In vitro <\/em>ADME<\/h2>\n
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In vivo <\/em>PK<\/h2>\n
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Metabolite Identification (MetID)<\/h2>\n
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Radiolabeled ADME<\/h2>\n
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Non-GLP Bioanalysis<\/h2>\n
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Digital Lab Operation<\/a><\/span><\/h2>\n
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DMPK\/ADME Studies for Your Molecule<\/h2>\n
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Our DMPK\/ADME Network<\/h2>\n